Association of DNA methylation profiles with MECOM expression. (A) Heatmap of DNA methylation profiles according to the methylation values at the 482 CpG sites associated with MECOM expression. Arrangement of 64 patients according to a series of MECOM expression values (more rightward column location indicates stronger PRDM16 expression) yielded 2 groups with distinct methylation patterns. This classification substantially distinguished patients with high and low MECOM expression (left). (B) Heatmap of 50 CpG sites associated with particularly large differences in methylation values between patients with high and low MECOM expressions (right).