Hemophilia A- and hemophilia B-related mutations to fVIIIa/fIXa dimer interface. Mutations at the fVIIIa:fIXa interface were identified from the CHAMP and CHBMP database, as collated by the Centers for Disease Control, and depicted in sphere representation on the crystal structure of human fVIII (PDB ID: 6MF2, top) for hemophilia A and SWISS-MODEL of human fIXa generated from porcine fIXa (PDB ID: 1PFX, bottom, Human Genome Variation Society (HGVS) numbering) for hemophilia B. Residues are colored by disease severity (blue: mild; yellow: moderate; red: severe).