Figure 4.
HAPC1573 (1573) antibody treatment restores the thrombin generation of plasma from PROC+/+;F8−/− mice. Platelet-rich plasma was prepared from blood taken from mice (n = 3) in 4 groups as indicated. PROC+/+;F8−/−mice were pretreated with or without FVIII (2 IU per mouse) or 1573 (20 µg per mouse) 30 minutes prior to being euthanized. The profile of thrombin generation was a representative of triplicate samples.

HAPC1573 (1573) antibody treatment restores the thrombin generation of plasma from PROC+/+;F8−/− mice. Platelet-rich plasma was prepared from blood taken from mice (n = 3) in 4 groups as indicated. PROC+/+;F8−/−mice were pretreated with or without FVIII (2 IU per mouse) or 1573 (20 µg per mouse) 30 minutes prior to being euthanized. The profile of thrombin generation was a representative of triplicate samples.

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