Patient flow and disposition. *Hepatitis, erythematous rash, and cerebral hemorrhage in 1 patient each. †Sudden death on study day 23 in a 54-year-old male with a medical history of hypertension, hyperlipidemia, smoking, fatigue, anxiety, depression, insomnia, and gastroesophageal reflux disease. ‡Hemorrhagic cerebral infarction and sinus arrest in 1 patient each. §Pneumonia and neutropenia + pharyngitis in 1 patient each. ǁPatient discontinued venetoclax due to an AE (nausea + vomiting) and subsequently discontinued ibrutinib due to investigator decision.