Summary of AEs for ibrutinib-treated patients. The most common any-grade (A) and grade ≥ 3 AEs (B) are shown by yearly interval. Prevalence was determined by the proportion of patients with a given AE (existing event or new onset of an event) during each yearly interval. Multiple onsets of the same AE term within a specific yearly interval were counted once, and the same AE term continuing across several yearly intervals was counted in each of the intervals. Atrial fibrillation and hypertension are shown in Figure 6. URTI, upper respiratory tract infection; UTI, urinary tract infection.