Model depicting hemogen function. The cooperativity of activating complex hemogen/BRG1/LDB1 establish open chromatin for enhancers (depicted) and promoters for key erythroid gene activation during mammal erythropoiesis. BasoE, basophilic erythroblasts; HSC, hematopoietic stem cell; OrthoE, orthochromatophilic erythroblasts; Pol II, RNA polymerase II; PolyE, polychromatic erythroblasts; ProE, proerythroblast; RBC, red blood cell.