GSEA and DEGs between HAVCR2^Y82C and HAVCR2^WT SPTCLs. (A) Significantly enriched gene sets in HAVCR2^Y82C SPTCLs and their NES are shown. (B) Most enriched gene set in HAVCR2^Y82C SPTCLs were associated with increased inflammatory responses. (C) Higher number of pSTAT3-positive cells characterizes HAVCR2^Y82C SPTCLs. (D) Volcano plot highlighting 52 genes differentially expressed according to HAVCR2 genotype. (E) CCR4 and Foxp3 positivity was assessed by using IHC. Correlation plot showing percentages of CCR4- and Foxp3-positive cells; circled cross indicates outlier results. (F and G) HAVCR2^WT SPTCLs had a significantly higher number of CCR4-positive cells and Foxp3-positive cells compared with HAVCR^Y82C SPTCLs (Mann-Whitney U test).