Cryo-electron microscopy of releasate from SARS-CoV-2–infected cells. (A) A set of EVs, ranging in size from 100 to 500 nm. Some EVs contain smaller EVs, as frequently observed in EV samples from various origins. (B) Two EVs side-by-side. One EV is specifically labeled with Anx5 gold particles, thus exposing the procoagulant lipid phosphatidylserine; the other one is unlabeled, thus does not expose phosphatidylserine. (C) A group of virus particles, characterized by their homogenous granularity and the presence of long protein protrusions (white arrows) corresponding most likely to spike proteins. (A-C) The white stars indicate thin threads of the carbon support film.