Graphical summary of the described mechanism. (A) SARS-CoV-2–infected cells release virus and EVs with associated TF activity. (B) This initiates the TF pathway of coagulation in plasma, thereby converting prothrombin into thrombin. Thrombin signals to platelets via PAR-1 and PAR-4. (C) Platelet activation is characterized by the expression of activated integrin αIIbβ3 and P-selectin, degranulation, aggregation, and the release of EVs. The graphical summary was created with BioRender.com.