Proportion of IGLV3-21 gene and allele usage, and R110 mutation in lambda-expressing CLL. (A) Results of the present cohort of 45 familial lymphoproliferative disorder cases (41 familial CLL, 4 families with CLL and another B-cell malignancy including 2 Hodgkin lymphoma, 1 follicular lymphoma, 1 nonspecified non-Hodgkin lymphoma). (B) Results from public datasets (pooled data from supplemental material published elsewhere^8,9 ).