Spatial features of the TME associated with CR to second-line Nivo. (A) Density of CD8⁺PD-1⁺ T cells in CR vs non-CR patients. (B) Density of CD163⁺PD-L1⁺ macrophages in CR vs non-CR patients. (C) CD8⁺PD-1⁺ T cells within 40 μm of HRS cells in CR vs non-CR patients. (D) CD163⁺PD-L1⁺ macrophages within 40 μm of HRS cells in CR vs non-CR patients. (E) CD56⁺ NK cells within 40 μm of HRS cells in CR vs non-CR patients.