Reduction in virus neutralization sorted by plasma type as well as an increase by Euroimmun antibody levels. (A) WA-1, δ, and ο virus microneutralization sorted by the 108 CCP units, post-δ COVID-19/post vaccination, and hyperimmunoglobin. IU/mL geomeans are shown above x-axis. (B) Antibody levels over 3.5 Euroimmun AU show 85% microneutralization with WA-1 and δ, whereas ο neutralization requires Euroimmun AU over 10 for 85% of the 108 CCP donors. Post-δ COVID-19/postvaccination retains 100% virus neutralization for the 3 variants. Virus neutralization is any positive IU/mL over 1. (C) Range of Euroimmun antibody levels sorted by prevaccination 2020 donor collections and early January to March 2021 for the large number of clinical trial donors and the 108 remnant donors. Geomeans near x-axis and number above 10 AU in red above values. More than 10% of units have Euroimmun AU over 10 except for the 2020 remnant units. Three of the 12 2021 108 donors were vaccinated along with documented COVID-19. The vaccine status of the other 9 was not recorded at time of donation. The P values were Tukey’s multiple comparisons of 1-way ANOVA. ****P < .0001; ***P < .001; **P < .01. AU, arbitrary units.