Pharmacologic inhibition of CD47 with Dara elevates ADCP in T-ALL cells. (A-B) ADCP in P12 (A) and MOLT-13 (B) subjected to Dara or SEN177 (10 µM; 72 hours) alone, the combination of both (Dara + SEN177 [combi]), or dimethyl sulfoxide (DMSO) (solvent control). Graph depicts 4 independent experiments with different human macrophages (n = 4, standard error of the mean). (C) ADCP in 2 random de novo (patients #2 and #10) and 2 r/r (patients #6r/r and #10r/r) T-ALL PDX samples treated with Dara or SEN177 (10 µM; 72 hours) alone, the combination of both (Dara + SEN177 [combi]), or DMSO (solvent control). One representative experiment of 4 experiments with different donor macrophages is depicted. Nonparametric Mann-Whitney U test (two-tailed). *P < .05. ROI, red object counts per image.