Flowchart of MRD response by MFC and NGS at various time points. Discordance rates were calculated including only patients who were assessed as either MRD-positive or -negative by NGS at a sensitivity of 10⁻⁶ and excluding patients who were MRD indeterminate by NGS at 10⁻⁶. One MRD sample at time of CR and at 1.5 to 3 months was indeterminate by MFC; in both cases, MRD was detected by the NGS assay. MRD^pos, MRD⁺; MRD^neg, MRD⁻; MRD^ind, MRD indeterminate.