Recombinant fibrinogen variants γDEK, γD297N, γE323Q, and γK356Q affect fiber thickness. Micrographs were taken at ×20 000 magnification using a Hitachi SU8230 scanning electron microscope (A-E). Compared with WT (A), fibrin fibers of γDEK (B, F), γD297N (C, F), γE323Q (D, F), and γK356Q fibers (E, F) were thinner. Mean ± SD, N = 3 (WT, γDEK, γD297N), N = 4 (γK356Q), N = 5 (γE323Q). *P < .05; **P < .01; ***P < .001 compared with WT.