Distribution of IGHV gene segments in patients with LPL/WM. (A) IGHV gene usage in patients with LPL/WM. (B) Top 31 IGHV genes expressed in our series are shown along the x-axis. (C) IGHV distribution in LPL/WM and normal B cells. *P < .05, **P < .01, ***P < .001.