Distribution and associations of IGH gene segments in patients with LPL/WM. (A) Distribution of IGHD gene repertoire in patients with LPL/WM. (B). Distribution of IGHJ gene repertoire in patients with LPL/WM. Circular graphs of the associations between (C) IGHV and IGHD segments and (D) IGHV and IGHJ segments in patients with LPL/WM. The Comprehensive R Archive Network software package (https://mirrors.tuna.tsinghua.edu.cn/CRAN/) was used analyze IGHV segment combinations with IGHD and IGHJ segments.