AID alters the expression of molecules related to cell survival and DNA damage in BCR-ABL1⁺ B-ALL cells. (A) Expression profiles of genes within cluster 12. (B) KEGG pathways analysis of differential expressed genes (fragments per kilobase per million [FPKM] ≥ 2) from cluster 12. (C) qRT-PCR validation of RNA-seq at selected target genes, Gapdh was used to normalize cDNA amounts. (D) KEGG pathway analysis of DDR-related genes. (E) Heatmap of showed differential expression of DDR-related genes between the 2 comparisons (AID WT + LPS vs AID KO + LPS, AID WT + PBS vs AID WT + LPS). The red color indicates upregulation in the latter group compared with the former group, and the blue color indicates the reverse. (F) The RNA-seq results of selected genes were verified by qRT-PCR. Gapdh was used to normalize cDNA amounts. qRT-PCR data are representative of at least 3 independent experiments. Error bars represent the mean ± standard error of the mean. *P < .05, ***P < .001.