TAMs have unique gene expression signatures. (A) Principal component analysis plot comparing transcriptomes of naïve MPs, TAM-ICs, and TAM-NICs. (B) Venn diagrams comparing DEGs between 3 MP subsets. (C) Unsupervised clustering of all DEGs from 3 pair-wise comparisons: TAM IC vs TAM NIC, TAM IC vs MP, and TAM NIC vs MP. (D) GO analysis (biological process terms) for gene clusters upregulated commonly or uniquely in the 2 TAM subsets vs MPs.