Figure 4.
The landscape of structural variants in r/r LBCL and outcome association. (A) Stacked bars show the genome-wide burden of each SV class and complex event per each sample (x-axis, 51 WGS samples from 49 patients). (B) Copy number profile plot integrated with SV information showing an emblematic example of chromothripsis on chromosome 9 responsible of CDKN2A loss (sample CAR_39). The horizontal black line indicates the total copy number; the dashed orange line indicates the minor copy number. The vertical lines represent SV breakpoints, color-coded based on SV class. Red text represents the DLBCL driver genes present on chromosome 9. (C) Kaplan-Meier plot for PFS comparing patients with LBCL, with and without chromothripsis (n = 47) (D-E) Examples of double minutes involving MYC (D) and Kaplan-Meier plot for PFS, comparing patients with DLBCL, with and without double minutes (n = 38).

The landscape of structural variants in r/r LBCL and outcome association. (A) Stacked bars show the genome-wide burden of each SV class and complex event per each sample (x-axis, 51 WGS samples from 49 patients). (B) Copy number profile plot integrated with SV information showing an emblematic example of chromothripsis on chromosome 9 responsible of CDKN2A loss (sample CAR_39). The horizontal black line indicates the total copy number; the dashed orange line indicates the minor copy number. The vertical lines represent SV breakpoints, color-coded based on SV class. Red text represents the DLBCL driver genes present on chromosome 9. (C) Kaplan-Meier plot for PFS comparing patients with LBCL, with and without chromothripsis (n = 47) (D-E) Examples of double minutes involving MYC (D) and Kaplan-Meier plot for PFS, comparing patients with DLBCL, with and without double minutes (n = 38).

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