Tornado diagram of one-way sensitivity analysis of the GRIFFIN model (Japanese analysis). (A) Incremental cost and (B) incremental effectiveness of D-RVd vs RVd. Red bars represent changes in values when parameters were varied from base case to higher uncertainty value. Blue bars represent changes in values when parameters were varied from base case to lower uncertainty value. Only parameters that produce >¥1 000 000 change in costs and 0.01 QALY change in effectiveness were included in the diagram. *Probability of withdrawal from second-line treatment was the only parameter that may reverse the incremental cost of D-RVd vs RVd.