AEIs are reported by category and severity (all grade and grade ≥3). See supplemental Table 1 for a description of criteria that define each category of AEI. Neutropenia includes the PTs neutropenia (n = 104), neutrophil count decreased (n = 184), febrile neutropenia (n = 15), and neutropenic sepsis (n = 1); anemia includes the PTs anemia (n = 131) and hemoglobin decreased (n = 6); and thrombocytopenia includes the PTs thrombocytopenia (n = 65) and platelet count decreased (n = 107). Hypertension includes the PTs hypertension (n = 91) and blood pressure increased (n = 6). Hemorrhage is inclusive of major hemorrhagic events (also reported separately); second primary malignancies include skin cancers (reported separately); and infections include opportunistic infections (reported separately).