Specific features of DDX41^MutGL compared with DDX41^WT AML patients. (A) Volcano plot representing the association between DDX41^MutGL variants and clinical and biological covariates (estimate of the point–biserial correlation [continuous variables] or F [dichotomous variables] on the x-axis) and the significance of the difference, expressed on an inverted logarithmic scale on the y-axis. The P values were calculated by using the Mann-Whitney U test (continuous variables) or Fisher’s exact (dichotomous) test. The size of the circle corresponds to the frequency of the variable in the cohort. For statistical power consideration, we used only variables with frequency >1% in the whole cohort (ie, >15 patients). Tests were corrected for multitesting using false discovery rate (FDR). (B) Molecular and cytogenetic characteristics of patients with AML enrolled in the ICT trials according to DDX41^MutGL status. (C) Box plots showing the number of co-occurring somatic mutations in DDX41^MutGL and DDX41^WT AML. The P value was calculated by using the Mann-Whitney U test and corrected for multitesting by using FDR. (D) ELN-2017 stratification according to DDX41^MutGL status.