Clonal architecture of DDX41^MutGL AML. (A) Relative CCFs of somatic mutations. CCFs are normalized on the highest CCF in each patient (assuming a linear accumulation of mutations). Isolated DDX41^MutSom mutations are considered separately for unbiased representation. Only the most recurrent mutations are shown. (B) Correlation between the percentage of bone marrow blasts and the CCFs of DDX41^MutSom variants. Results of the Spearman correlation test are reported. (C) Mutational landscape of 10 diagnostic/relapse DDX41^MutGL AML sample pairs. Each column represents a single patient. (D-E) Fish plots derived from CALDER clonal architecture inference (upper panel) and corresponding raw VAF (lower panel) visualizing patterns of clonal evolution in 2 characteristic DDX41^MutGL AML patients.