Failure of FDCT and subsequent treatments received after first definitive cellular therapy. (A) Cumulative incidence of patients receiving a second or greater therapy (ERT, GT, or HCT) after FDCT, according to FDCT received. (B) Swimmer plot showing second or greater therapy received after FDCT. Subsequent treatments are represented as circles (ERT), squares (GT), or triangles (HCT). Horizontal arrow means the patient is alive at last follow-up. No arrow means the patient died at that point in time after FDCT. Green bars represent patients receiving HCT as FDCT. Blue bars represent patients receiving ERT-GT as FDCT. All 4 patients receiving ERT-GT requiring subsequent therapy received retroviral vectors as FDCT (no patients receiving GT with lentiviral vectors required additional therapy), and ERT after GT as their second therapy. Red bars represent patients receiving ERT-HCT as FDCT.