Clone C CAR T cells control tumor growth and prolong survival in leukemia and mesothelioma mouse models. (A) Experimental design for BV173 intravenous (i.v.) leukemia model. (B) Mean tumor burden as defined by percentage of A*02–positive blast cells in mouse blood. Five mice per group. **P < .01 (Mann-Whitney text). Error bars denote standard deviation. (C) Overall survival in BV173 leukemia model. *P < .05, **P < .01 (log-rank test). Experiment was conducted twice, with comparable results. (D) Experimental design for JMN intraperitoneal (i.p.) mesothelioma model. (E) Spaghetti plot depicting individual tumor burden relative to day 3. (F) Geometric mean of average tumor burden spaghetti plot depicting individual tumor burden relative to day 3. Five mice per group. *P < .05, **P < .01 (Mann-Whitney test). Error bars denote 95% confidence interval. (G) Bioluminescence imaging using luciferase pre– and post–CAR T-cell treatment. (H) Overall survival in JMN mesothelioma model. **P < .01 (log-rank test). Experiment was conducted twice, with comparable results. D, day; n.s., not significant.