Private SVs cause massive MAFA overexpression and reprogramming to MAF-type MM. (A) Heat maps displaying the number of read clouds shared between indicated regions on chromosome 1 (chr1) and chr8. The connected green and orange arrows schematically indicate the areas joined by the SV. The type of SV is indicated. (B) Schematic representation of the derivate chromosomes. (C) Tracks showing the H3K27Ac signal (median ± standard deviation [SD]) in the regions involved in t(1;8). (D) Expression of MAFA. (E) Row-normalized hierarchically clustered heat map of H3K27Ac-marked regions showing differential signals between MM subtypes. PB, plasmablast; t(nr), nonreciprocal translocation.