Effect of sutimlimab on markers of hemolysis from baseline to week 26. (A) Analysis of the change from baseline in bilirubin excluded patients with either a positive Gilbert syndrome genetic test or no test result. Overall, 21 of 22 patients in the sutimlimab arm and 18 of 20 patients in the placebo arm consented to receive Gilbert syndrome testing. Of these, no patient had a positive result, and 1 patient had unknown result and was excluded from the analyses. The normal range for bilirubin was defined as 5.1 to 20.5 µmol/L. (B) Normalization of haptoglobin was defined as greater than the level of haptoglobin detection. (C) Parameters for reticulocyte normalization were not defined for this study. (D) The normal range for LDH was defined as 120 to 246 U/L. B, baseline.