Figure 5.
Cytokine/chemokine secretion in response to BMX inhibition or knockout. (A) Cytokines/chemokines secreted by MV4-11 wild-type and BMX CRISPR KO cells, after 72 hours in hypoxia (Luminex multiplex assay, n = 2). Representative data from two independent experiments are shown. Cytokines/chemokines secreted by (B) MV4-11 and (C) MOLM-13, after growth in hypoxic conditions for 24 hours, followed by treatment with CHMFL-BMX-078 (3 and 5 μM, respectively) for 48 hours (Luminex multiplex assay, n = 2). Representative data from two independent experiments shown. (D) Secretion of cytokines/chemokines by human primary FLT3+ AML samples cultured in hypoxia for 24 hours, followed by treatment with CHMFL-BMX-078 for 48 hours (Luminex multiplex assay, n = 2). For statistical analysis, *P ≤ .05; **P ≤ .01; ***P ≤ .001, as determined by two-tailed, unpaired Student t test.

Cytokine/chemokine secretion in response to BMX inhibition or knockout. (A) Cytokines/chemokines secreted by MV4-11 wild-type and BMX CRISPR KO cells, after 72 hours in hypoxia (Luminex multiplex assay, n = 2). Representative data from two independent experiments are shown. Cytokines/chemokines secreted by (B) MV4-11 and (C) MOLM-13, after growth in hypoxic conditions for 24 hours, followed by treatment with CHMFL-BMX-078 (3 and 5 μM, respectively) for 48 hours (Luminex multiplex assay, n = 2). Representative data from two independent experiments shown. (D) Secretion of cytokines/chemokines by human primary FLT3+ AML samples cultured in hypoxia for 24 hours, followed by treatment with CHMFL-BMX-078 for 48 hours (Luminex multiplex assay, n = 2). For statistical analysis, *P ≤ .05; **P ≤ .01; ***P ≤ .001, as determined by two-tailed, unpaired Student t test.

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