A potential strategy for refining the classification of hematologic neoplasms to improve patient care through the implementation of precision treatments. The different processes could be coordinated by an International Working Group (IWG), which would oversee the classification. The current International Consensus classification, with its strong morphology component, will represent a basis for refinement. Access to patient data would be important for allowing the use of various methods of inference aimed at identifying distinct disease subgroups. A collaborative clinico-pathologic CAC review process will provide a mechanism to update pathologic and genomic criteria within clinical context. An interactive Web-based portal, also accessible through a mobile app, would make the classification more immediately available to the scientific community.