Prognostic significance of DNMT3A mutations in peripheral T-cell lymphoma entities. (A) Kaplan-Meier curve of the OS of DNMT3A-MT and WT cases for the entire PTCL cohort. All patients were treated with a CHOP-based regimen. (B) OS for DNMT3A-MT and WT cases for PTCLs of T_FH origin (AITL n = 89, PTCL_TFH-like = 15). (C) OS for DNMT3A-MT and WT cases for PTCL-GATA3. (D) OS for DNMT3A-MT and WT cases for PTCL-TBX21. (E) OS comparison of PTCL-TBX21 and PTCL-GATA3 cases with respect to DNMT3A mutation status. (F) OS of DNMT3A mutants within the dimerization region (881-887), other DNMT3A mutants, and WT cases for the entire PTCL cohort. MT, mutant.