MH-fusion drove BCP-ALL in combination with NRAS^G12D mutation. (A) Kaplan-Meier survival analysis of WT, NRAS^G12D, MH, and MH/NRAS^G12D mice. The sample size (n) used in this study is indicated. (B) The WBC, hemoglobin (Hgb), and platelet levels of the MH/NRAS^G12D mice who died were compared with the WT, NRAS^G12D, and MH mice at the same age. (C) Morphologic analysis with Wright’s staining of the cells in PB, BM, and spleen of WT, NRAS^G12D, and MH/NRAS^G12D mice. (D) FACS analysis of cells in the BM. (E) Spleen sizes from WT, NRAS^G12D, MH, and MH/NRAS^G12D mice. (F) Hematoxylin and eosin (HE)-stained sections of the spleen derived from WT, NRAS^G12D, and MH/NRAS^G12D mice. Data are presented as mean ± standard error of the mean and were analyzed by using the t test. *P < .05, **P < .01.