ADAMTS13 sSNVs may affect mRNA regions encoding the active site and metal-binding domains. Crystal structure of the ADAMT S13 domain (A) with the highlighted metalloprotease domain (B) and spacer domain (C) to display amino acid (AA) position that may be affected by synonymous variants of ADAMT S13. Specific ADAMT S13 domains are color coded: signal peptide = light blue; propeptide = blue; metalloprotease = yellow; disintegrin-like = gold; T1-T8 = green; C = cysteine-rich = gray; spacer = purple; CUB1 = ivory; and CUB2 = brown. (D) Number of ADAMT S13 sSNVs encoding specific amino acids (nonpolar in gray, polar in green, positively charged in red, negatively charged in blue) represented by blue bars and the number of each amino acid in ADAMT S13 represented by gold bars.