![STAT1-dependent MHCIIhi HSCs are less responsive to diverse stress stimuli. High levels of MHCII define a novel HSC subset dependent on STAT1. This subset is less responsive to stress-induced (5-FU or polyinosinic:polycytidylic acid [p:IC]) proliferation and apoptosis. In mutant CALR mice, MHCIIhi HSCs have a low capacity to expand and differentiate into the megakaryocytic lineage. Professional illustration by Somersault18:24.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/140/14/10.1182_blood.2022016850/2/blood_bld-2022-016850-c-gr1.jpeg?Expires=1736047368&Signature=Bvu9GeQLcbTnonLoW1g8zKsRP~18lWy2Q2sUpCJE~X3MGYScqRN20gcWh98O0NXPl1C9HGYZara2fbpa2WUQ1XQVVaIBp1dK2GYFNlBL-u~rf7xXhG22wnYFHXqKwPgc4tkGnB5IDy~puKcPokE-JakIvVDXBIgLLmpNFxAb6bkQvYEMXHVYITi-fnhIy2DMVCtEuTR3Ssg7olcouCVAnZ8nu7NFmGW8hVsQpoKU32ioMXD8JfemtyubgrRDvRXmb9jbqHH1MqSsS8GOWKQwQbybO5z7Hma6R3xSvozE25wKlOWqHcAyzbOs0mZC6uvSDADgrcKU-qD3lJw-WUaFYQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
STAT1-dependent MHCIIhi HSCs are less responsive to diverse stress stimuli. High levels of MHCII define a novel HSC subset dependent on STAT1. This subset is less responsive to stress-induced (5-FU or polyinosinic:polycytidylic acid [p:IC]) proliferation and apoptosis. In mutant CALR mice, MHCIIhi HSCs have a low capacity to expand and differentiate into the megakaryocytic lineage. Professional illustration by Somersault18:24.
