Effects of Met dietary depletion on AML cells. (A) In normal Met dietary replete conditions, AML cells are able to metabolize Met through various steps to SAM to support histone 3 lysine 36 trimethylation and transcription of key genes involved in leukemia cell survival and proliferation. (B) On Met depletion, or through pharmacologic targeting of the enzymatic steps that lead to the formation of SAM from Met, AML cells are unable to support their survival transcriptional programs, which in turn leads to cell death. Professional illustration by Patrick Lane, ScEYEnce Studios.