Expression signatures and clonality of T-cell subsets. (A-B) Expression of the cytotoxicity signature in the UAMS, UoH (A), and Zavidij et al¹⁵ (B) data sets. (C-D) The level of expression of exhaustion markers in the UAMS, UoH (C), and Zavidij et al¹⁵ (D) data sets. (E) Proportions of clonal T cells in each disease stage (left panel). Clonality of distinct T-cell subsets in each disease stage (right panel). (F) Genes enriched in nonexpanded polyclonal or expanded clonal CD8 Mem 2 cells. All genes with an adjusted P value of .05- and 1.5-fold enrichment, were labeled.