Evaluation of thrombotic microangiopathies presenting in the second and third trimesters. This schema highlights recommended testing to distinguish preeclampsia with severe features/HELLP from cm-TMA or TTP. Not all possible etiologies to consider are listed in this brief schema.

*ADAMTS13 testing may also be appropriate in patients with clinical picture consistent with HELLP syndrome to rule out TTP as an alternate etiology. ^†Other etiologies to consider with severe renal injury are severe hypertension or catastrophic antiphospholipid syndrome.

PT/PTT, prothrombin/partial thrombplastin time.