Comparison of RFS for patients after the first course of vemurafenib vs retreatment with vemurafenib. Median RFS was 12.7 months (95% CI, 4.2 months to not reached) for retreated cohort, which was not significantly shorter than the RFS of 19 months (95% CI, 12.5-53.9 months) after the first course of vemurafenib (P = .47).