Figure 1.
Numerous cytokinesare increased withdisease progression. Heat maps of cytokines detected in the plasma (A) and BM (B) of mice transplanted with Jak2WT or Jak2V617F (left) and mice transplanted with MPLWT or MPLW515L (right). N = 3 to 4 mice per group. Heat maps display the minimum and maximum values for each row independently. Principal component analysis of cytokine values detected in the plasma and BM of Jak2WT or Jak2V617F (C) or MPLWT or MPLW515L (D). G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN-γ, interferon gamma; LIF, leukemia inhibitory factor; M-CSF, macrophage colony-stimulating factor; PC1, principal component 1; TNFα, tumor necrosis factor α; VEGF, vascular endothelial growth factor.

Numerous cytokinesare increased withdisease progression. Heat maps of cytokines detected in the plasma (A) and BM (B) of mice transplanted with Jak2WT or Jak2V617F (left) and mice transplanted with MPLWT or MPLW515L (right). N = 3 to 4 mice per group. Heat maps display the minimum and maximum values for each row independently. Principal component analysis of cytokine values detected in the plasma and BM of Jak2WT or Jak2V617F (C) or MPLWT or MPLW515L (D). G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN-γ, interferon gamma; LIF, leukemia inhibitory factor; M-CSF, macrophage colony-stimulating factor; PC1, principal component 1; TNFα, tumor necrosis factor α; VEGF, vascular endothelial growth factor.

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