The effect of IUTs on perinatal outcomes. We compared outcomes in fetuses who were diagnosed prenatally and survived (group 1, blue fill) with those diagnosed prenatally who had a perinatal demise (group 2, green fill) and those who were postnatally diagnosed and alive (group 3, red fill). (A) Percentage of fetuses in whom hydrops had resolved at the time of birth (group 1: n = 12, group 2: n = 3, group 3: n = 4 with data available). P = .005 across groups, P = .01 between groups 1 and 3. (B) GA at delivery in weeks (group 1: n = 14, group 2: n = 4, and group 3: n = 11 with data available). P = .004 across groups, P = .003 between groups 1 and 3, P = .022 between groups 1 and 2. (C) APGAR scores at 5 minutes (group 1: n = 14, group 2: n = 2, group 3: n = 6 with data available). P = .03 across groups, P = .03 between groups 1 and 3. (D) Percentage of neonates who required invasive mechanical ventilation after birth (group 1: n = 14, group 2: n = 2, group 3, n = 8 with available data) P = .03 across groups, P = .052 between groups 1 and 3). (E) Length of neonatal hospitalization (group 1: n = 14, group 2: n = 1, group 3, n = 9 with data available) P = .04 across groups, P = .049 between groups 1 and 3. (F) Percentage with average or greater neurodevelopment (group 1: n = 11, group 3: n = 11 with data available). P = .04 between groups 1 and 3. In panels B, C, and E, each symbol represents 1 patient; triangles represent patients with nondeletion variants (Zurich-Albisrieden, Hb H Adana); and the horizontal line indicates the median. For comparisons between groups 1 and 3, ∗P ≤ .05, ∗∗P ≤ .01; ∗∗∗P ≤ .005. † Represents a patient who died after a 175-day hospital stay. (Kruskal-Wallis one-way analysis of variance test with pairwise comparisons was used to compare the continuous variables across the 3 groups, and Fisher’s exact test was used for ordinal variables).