STAG2m characteristics in patients with MN. (A) Representation of STAG2 variants detected, positioned on the STAG2 protein and its functional domains. The protein alterations are indicated on top of the corresponding mutation location, exon locations are indicated below the protein. (B) Comutational pattern in 91 patients with STAG2m MN. Each patient is represented by a column. The number reported in the box represents the VAF of each mutation. (C) OS for 88 patients with STAG2m MN. (D) OS for tMN vs dnMN in patients with STAG2m. STAG, STAG domain; aa, amino acid.