Complete blood count (CBC) abnormalities in Dnm2^het when compared with CTRL mice. (A) Comparison of WBC counts in female Dnm2^het and in CTRL mice aged 11 weeks and above (11-34 weeks: N = 4, 35-49 weeks: N = 5 and above, 50-72 weeks: N = 7 and above). Older female Dnm2^het mice have significantly decreased WBC compared with CTRL mice, affecting mainly neutrophils, starting at middle-age (∼40 weeks; age range, 11-34 weeks). This persists at older ages (age range, 50-72 weeks). (B) Comparison of hemoglobin levels in male Dnm2^het and CTRL mice aged 11 weeks and above (11-34 weeks: N = 6 and above, 50-72 weeks: N = 5 and above). Mildly decreased hemoglobin was observed in male Dnm2^het only. Error bars indicate SEM. Only marked, group-wise comparisons are significant. ∗P < .05, t-test. ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; ANC.AMC, combined absolute neutrophil and monocyte count; SEM, standard error of the mean; WBC, white blood cells.