Transient or sustained platelet reduction did not affect disease outcome. Eμ-myc 5849 immortalized tumor cells (2 × 10⁴) were transplanted IV on day 1, and acute thrombocytopenia was induced by APS IV injection on days 0, 3, and 6 in male WT C57BL/6 mice. Mice were analyzed on day 16. (A) WBC count, (B) lymphocyte count, and (C) spleen weight. Mean ± SEM. n = 4 to 8 mice per group. The data passed the Shapiro-Wilks normality test. One-way ANOVA with Tukey multiple comparison test. WT and thrombocytopenic Bcl-x^Plt20/Plt20 male mice were transplanted IV with Eμ-myc 5849 tumor cells (2 × 10⁴), and mice were analyzed on day 20. (D) WBC count, (E) lymphocyte count, (F) spleen weight, and (G) platelet count. Mean ± SEM. n = 4 to 8 mice per group. Each symbol represents an individual mouse. Student unpaired t test. ∗P < .05, ∗∗P < .0052, ∗∗∗P < .001, ∗∗∗∗P < .0001.