Proinflammatory BM microenvironment in Tpo^Tg mice. Cytokine and chemokine analysis of BM fluid from WT, Mpl^−/−, and Tpo^Tg mice with Proteome profiler array (mouse cytokine array panel A). The figure includes cytokine and chemokines that were detected in BM fluid and excludes proteins that were below detection level. n = 4 samples per genotype. Each sample was combined from 2 mice of the same genotype (a total of 8 mice were included per genotype). Data are presented as mean ± SEM. Only significantly different changes are indicated. 3 independent experiments. Student unpaired t test. ∗P < .05, ∗∗P < .005.