Elevated oxLDL and enhanced GPVI-mediated procoagulant platelet generation in obese nonhuman primates. Blood was collected from a cohort of lean (n = 6) and diet-induced obese (n = 6) rhesus macaques to prepare serum for analysis of triglycerides (A), total cholesterol (B), high-density lipoprotein cholesterol (C), LDL cholesterol (D), and oxLDL immunoreactivity (E). Citrate-anticoagulated whole blood from lean and obese animals was stimulated with GPVI agonist (0.1 μg/mL CRP-XL) or a combination of GPVI and PAR1 agonist (1 μg/mL CRP-XL, 20 μg/mL TRAP-6) before flow cytometry analysis of platelet α-granule secretion (F) and platelet PS exposure (G). Statistical analysis was performed using a one-way analysis of variance (ANOVA) test and the corresponding P values of significance are as indicated: ∗P < .01, ∗∗P < .001, and ∗∗∗P < .0001. CRP-XL, crosslinked collagen-related peptide.