Association of CHIP variants defined by minimum allele depth (minAD) strata with age and TERT promoter variant rs7705526. (A-D) Show the associations for strata of CHIP variants defined by minAD 3, 4, 5, and 6 with age (panels A, C) and the rs7705526 TERT promoter variant (panels B, D) in UKB and All of Us Cohorts. The right axis plots the results of a simulation experiment in which the specified proportion of samples in the minAD ≥5 CHIP data set was randomly exchanged for individuals without CHIP in the data set to estimate misclassification. Each simulation was run 20 times, and the average result is shown.