Spectrum of mutations in the pre- and postoperative blood and BM sample of patients with CH. (A) Oncoprint for all study participants based on preoperative PB and BM findings. Each row represents a gene, and each column corresponds to a study participant. Bar plots indicate the number of mutations per patient (top bar plot) and the number of patients with mutations in each gene (side bar plot). For each patient, bottom panels indicate age, sex, prior cancer history, prior exposure to chemotherapy and/or radiation, and blood parameters. (B) VAFs of variants found in the BM are plotted against VAFs of variants found in the corresponding preoperative PB. Most patients showed concordance between VAFs in the BM and VAFs in the preoperative PB. (C) VAFs of variants found in the postoperative PB are plotted against VAFs found on the preoperative baseline PB sample. VAFs in the baseline sample correlated well with postoperative VAFs in follow-up PB samples. Pearson correlation is shown (95% confidence interval) for panels B and C. ALL, acute lymphoblastic leukemia; CML, chronic myeloid leukemia; cor, correlation; Hgb, hemoglobin; HL, Hodgkin lymphoma; RDW, red cell distribution width; TGCT, tenosynovial giant cell tumor; WBC, white blood cells.