K3 promotes integrin expression and activation on BM EBs and macrophages. (A) Overlays of representative histograms of fluorescence-activated cell sorter analysis of integrin αV (top) and β3 (middle) expression as well as soluble Fg binding (bottom) to the gated F4/80⁺ macrophage populations from mouse BM. (B) Statistical comparison of data shown in panel A. ∗P < .001; mutant vs K3WT strains; n = 5 mice per strain. (C) Overlays of representative histograms of fluorescence-activated cell sorter analysis of integrin α4 (top), total β1 (middle), and activated β1 (bottom) expression in the gated Ter119⁺ erythroid cells from mouse BM. (D) Statistical comparison of data shown in panel C. ∗P < .001; mutant vs K3WT strain; n = 5 mice per strain.