Functional pathway enrichment and PPI of the candidate genes. (A) Functional pathway enrichment with GO, KEGG, and Reactome comparing across all time points of significant EtoRGs (12 genes for day 4, 25 genes for day 12, 19 genes for day 18) and EtoSGs (160 genes for day 4, 69 genes for day 12, 72 genes for day 18). (B) STRING PPI network of 50 genes with at least 2 significant time points (nodes represent proteins, and edges connecting nodes represent interaction with concealing singletons). (C) The IPA canonical pathway hierarchical clustering of 50 significant candidate genes over 3 time points reveals shared canonical pathways (FDR < 0.05).