Impact of siRNA-mediated knockdown of TOP2A, RAD54L2, PRKDC, and ZNF451 on etoposide sensitivity. (A and C) The bar plots depict the effect of siRNA-mediated knockdown on etoposide sensitivity in relative cell viability (%) for Kasumi-1 (A) and KG-1 (C) cells. (B and D) Confirmations of siRNA knockdown are shown in relative messenger RNA expression (%) by quantitative PCR for Kasumi-1 (B) and KG-1(D) cells. Data are presented as mean ± standard deviation. Relative cell viability bar plots are representative with 3 technical replicates for each sample, whereas quantitative PCR experiments included 2 technical replicates for each sample. (∗, ∗∗, ∗∗∗, ∗∗∗∗ indicate significant terms at the P < .05, P < .01, P < .001, and P < .0001 statistical levels, respectively).